Research Articles
Measuring Microtubule Dynamic Instability: From Foundational Concepts to Advanced Techniques for Research and Drug Discovery
This article provides a comprehensive guide to the current methodologies for quantifying microtubule dynamic instability, a fundamental process in cell division, signaling, and organization.
Network Analysis of the Cytoskeleton: Unveiling Organizational Principles for Biomedical Research and Drug Discovery
This article synthesizes foundational and emerging paradigms in cytoskeleton research, focusing on the application of network analysis to decode its complex architecture.
Cytoskeletal Alterations in Age-Related Diseases: A Transcriptomics Perspective for Biomarker and Therapeutic Discovery
This article synthesizes current research on transcriptomic alterations in cytoskeletal genes across major age-related diseases, including neurodegenerative and cardiovascular conditions.
Mechanical Properties of Cytoskeletal Components: A Comparative Analysis for Biomedical Research
This article provides a comprehensive comparison of the mechanical properties of the three core cytoskeletal components—actin filaments, microtubules, and intermediate filaments.
Cytoskeletal Gene Classifiers: Revolutionizing Disease Diagnosis Accuracy with Machine Learning
This article explores the transformative role of cytoskeletal gene expression profiles as powerful biomarkers for accurate disease diagnosis.
Quantifying Microtubule Orientation: From Light Microscopy to Advanced Imaging in Cellular Research
This article provides a comprehensive overview of the methodologies and tools for quantifying microtubule orientation, a critical parameter in cell biology with implications for neuronal development, disease research, and drug...
Cytoskeletal Remodeling in E-cadherin Mutant Cells: From Architecture to Invasion
This article synthesizes current research on how E-cadherin dysfunction, a hallmark of epithelial cancers and hereditary diffuse gastric cancer (HDGC), triggers profound reorganization of the cytoskeleton.
Beyond Randomness: Uncovering Actin-Microtubule Network Principles with Null Models
This article provides a comprehensive framework for understanding the emergent properties and organizational principles of the composite actin-microtubule cytoskeleton.
Cytoskeletal Blueprint of Invasion: Decoding Architectural Cues in Cancer Cells for Diagnostic and Therapeutic Advancements
This article provides a comprehensive analysis of the distinct cytoskeletal architectures that differentiate invasive from non-invasive cancer cells, tailored for researchers and drug development professionals.
A Computational Workflow for Cytoskeletal Gene Biomarker Identification: From Discovery to Clinical Translation
This article provides a comprehensive guide to the computational identification of cytoskeletal gene biomarkers, a promising frontier for diagnosing and treating age-related and chronic diseases.